The T-cell-receptor signaling network

The T-cell-receptor signaling network.

T-cell-receptor (TCR) signaling in response to antigen recognition has a central role in the adaptive immune response. Furthermore, the comprehensive nature of the TCR signaling network is such that it has become a model system for complex cellular responses ranging from gene regulation to cytoskeletal remodeling. Over the past five years, our understanding of TCR signaling has evolved on a num...

Recent Advances in T Cell Signaling in Aging

The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...

T-cell activation: a multidimensional signaling network.

Naïve T cell activation requires the interactions of antigen receptors, adhesion molecules and co-stimulatory molecules. Antigen receptors and adhesion molecules are involved in spatio-temporal movement to form a stable immunological synapse. This stable junction interrupts T cell migration, and provides a platform for temporally regulated co-stimulatory receptor signaling spanning a period of ...

Viral modulation of T-cell receptor signaling.

Glucocorticoids Attenuate T Cell Receptor Signaling

Glucocorticoids (GCs) affect peripheral immune responses by inhibiting T cell immunity at several stages of the activation cascade, causing impaired cytokine production and effector function. The recent demonstration that the thymic epithelium and possibly thymocytes themselves produce steroids suggests that endogenous GCs also play a role in the control of T cell development. As both periphera...